Which statement best describes the use of Niacin in cholesterol therapy?

Niacin, also known as vitamin B3, is particularly noted for its ability to effectively raise high-density lipoprotein (HDL) cholesterol levels. HDL is often referred to as "good" cholesterol because it helps transport cholesterol to the liver for excretion, reducing the risk of atherosclerosis and cardiovascular diseases. Niacin plays a unique role in cholesterol therapy primarily because of its positive impact on HDL levels rather than its effect on low-density lipoprotein (LDL) cholesterol, which is more effectively targeted by other lipid-lowering agents like statins.

While Niacin does have some effects on lowering LDL levels and triglycerides, its most distinguishing and clinically significant benefit lies in its capacity to elevate HDL levels. This feature makes it a valuable option in certain patients who have low HDL or those with a specific cholesterol profile.

The therapeutic use of Niacin has been scrutinized in recent years, particularly due to concerns regarding the overall cardiovascular risk reduction and potential side effects. However, it is not completely disregarded; its unique effects on HDL should be acknowledged in appropriate patient populations.